The prime minister spoke to Sky News ahead of her chancellor announcing new tax policies on Friday. Taking a bullish stance, she insisted she would push ahead whatever the consequences.
Liz Truss has said she is prepared to be unpopular with her tax policy as she believes it will ultimately benefit the British economy.
Talking to Sky News' political editor Beth Rigby in New York, the prime minister defended any tax changes her government will make at the end of the week and said she will do what she has to do to get the economy growing again.
She also dismissed concerns around government plans to borrow more instead of taxing energy companies' profits (a windfall tax) and said she does not accept cutting taxes is unfair.
Asked if she was prepared to be unpopular with her policies, Ms Truss said: "Yes, yes I am.
"What is important to me is that we grow the British economy, because that is what will ultimately deliver higher wages, more investment in towns and cities across the country, that is what will ultimately deliver more money into people's pockets, and it will also enable us to fund the services like the National Health Service.
"And in order to get that economic growth, Britain has to be competitive."
She said putting up taxes, placing "arbitrary taxes" on energy companies or having high corporation tax would result in a lack of investment and growth which she said "will ultimately damage opportunities in this country".
Ms Truss defended reports that Chancellor Kwasi Kwarteng will scrap caps on bankers' bonuses during a mini budget announcement on Friday as she blamed the UK's "relatively low growth" on a lack of capital investment.
"We haven't had enough capital investment and yet we have one of the world's best financial services centres," she said.
"So what I want to see is that money in the City of London put to good use across our country - and yes, I'm prepared to do what it takes to get that money flowing."
As she further laid the path for the bankers' bonus announcement and tax-cutting, the PM admitted her tax cuts would disproportionately benefit the rich.
"I don't accept this argument that cutting taxes is somehow unfair," she said.
"I mean, what we know is that people on higher incomes generally pay more tax.
"So when you reduce taxes, there is often a disproportionate benefit because those people are paying more taxes in the first place.
"We should be setting our tax policy on the basis of what is going to make our country most successful, what is going to deliver that economy that benefits everyone in this country."
While the prime minister remained bullish about her tax policies, she did admit it will be a "tough winter".
But she added: "I'm determined my government takes every step and strains every sinew to get the economy going, to make sure we have a successful economy and as a country we can weather this storm.
"We will get through it."
Earlier in the day, the PM promised the UK would not bring in energy rationing this winter as some countries, such as Germany, have done.
She said the UK - and the West - "cannot jeopardise our security for the sake of cheap energy" as she pushed for other countries to commit to continue supporting Ukraine after announcing the UK will match the more than £2.3bn military aid it provided this year.