The US tech firm wants to replace three old warehouses with two major fulfilment centres and admits it will be more difficult to secure new work for some of the workers affected.
Amazon has revealed plans to shut three UK warehouses, a decision that will affect 1,200 jobs, but open two new major fulfilment centres.
Sites in Hemel Hempstead, Doncaster and Gourock, in the west of Scotland, have been proposed for closure.
A spokesman said all the workers would be offered roles at other existing Amazon locations.
A union representing some of the workers at the Hemel Hempstead site expressed disappointment over the decision and was sceptical about the prospect of acceptable, alternative work being found for each person affected.
Amazon said its planned new sites - at Peddimore in the West Midlands and Stockton-on-Tees in the North East - would result in the creation of 2,500 jobs over the next three years.
The company said: "We're always evaluating our network to make sure it fits our business needs and to improve the experience for our employees and customers.
"As part of that effort, we may close older sites, enhance existing facilities or open new sites, and we've launched a consultation on the proposed closure of three fulfilment centres in 2023.
"We also plan to open two new fulfilment centres creating 2,500 new jobs over the next three years.
"All employees affected by site closure consultations will be offered the opportunity to transfer to other facilities and we remain committed to our customers, employees and communities across the UK."
Gourock is home to the fewest number of employees, at 300, but it has less scope for alternative work in the surrounding area within Amazon.
The company acknowledged this and said they were to be offered retraining and reskilling opportunities as part of efforts to secure new work.
Steve Garelick, GMB union officer for Hemel Hempstead, said: "Disappointed for the workers and disappointed for the town and a deep concern this is the thin end of the wedge for the local area.
"Some workers may be offered alternative roles but decamping to Luton, Dunstable or Milton Keynes isn't as practical as you might think."
The announcement followed a group decision last week to axe 18,000 jobs globally, making Amazon the latest US tech firm to slash its workforce in the tougher economy.
Amazon has more than 1.5 million employees around the world - with 300,000 in corporate roles which were most likely to be affected by the worldwide cuts.